Research reagents for the detection of antibodies in animal sera by ELISA. Each ELISA plate is coated with mouse Cytomegalovirus (MCMV) Cytomegalovirus strain Smith: a purified inactivated whole virus propagated in SC-1 cells. Will cross react with other Cytomegalovirus.
Mouse Cytomegalovirus is a large, double stranded DNA virus of the family Herpesviridae, genus Betaherpesvirus. The virus commonly infects the salivary glands, and thus transmission of the virus occurs via transmission of infectious saliva. Latent infection can also occur in the pancreas, kidneys, liver, spleen and testicles. Adults are more frequently infected than young mice, and infection can persist for life. Natural infection of cytomegalovirus is usually asymptomatic, with pathological changes limited to nuclear inclusions and megalic cells found in the salivary glands. In experimental infection, lesions may develop in the salivary glands, liver, spleen, and lymph nodes. Wild mice are the only natural hosts of this virus.
National Research Council (US) Committee on Infectious Diseases of Mice and Rats. Infectious Diseases of Mice and Rats. Washington (DC): National Academies Press (US); 1991.
Baker DG. Natural pathogens of laboratory mice, rats, and rabbits and their effects on research. Clin Microbiol Rev. 1998;11:231–266.
Waggie, Kimberly S. Manual of Microbiologic Monitoring of Laboratory Animals. U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Center for Research Resources, 1994.