Research reagents for the detection of antibodies in animal sera by ELISA. Each ELISA plate is coated with Ectromelia Virus (Ectro) Poxvirus strain Moscow: a purified inactivated whole virus propagated in BS-C-1 cells. Will cross react with other Poxvirus.
Ectromelia Virus is a large, oval shaped DNA virus of the family Poxviridae, genus Orthopoxvirus. Transmission of Ectromelia Virus, also known as mousepox, occurs primarily through exposure of skin abrasions to a contaminated environment. Approximately 7-10 days after infection, skin lesions develop and shed additional virus to the environment. Severe necrosis of the liver, spleen, thymus, and lymph nodes will occur in acute cases. Morbidity can vary in laboratory colonies depending on environmental factors. Certain strains of mice have very high mortality rates associated with mousepox. Mice are the only natural hosts of this virus.
National Research Council (US) Committee on Infectious Diseases of Mice and Rats. Infectious Diseases of Mice and Rats. Washington (DC): National Academies Press (US); 1991.
Baker DG. Natural pathogens of laboratory mice, rats, and rabbits and their effects on research. Clin Microbiol Rev. 1998;11:231–266.
Waggie, Kimberly S. Manual of Microbiologic Monitoring of Laboratory Animals. U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Center for Research Resources, 1994.