Research reagents for the detection of antibodies in animal sera by ELISA. Each ELISA plate is coated with Lymphocytic Choriomenigitis Virus (LCM) Arenavirus strain Armstrong: The antigen is a purified inactivated whole virus propagated in L cells.
Lymphocytic Choriomeningitis Virus (LCMV) is a single stranded RNA virus of the family Arenaviridae, genus Arenavirus. Mice and hamsters host and transmit the virus, and many other animals are susceptible including humans, monkeys, dogs, rats and guinea pigs. Shedding of the virus occurs in the urine, saliva, and milk. Post-natal infection of mice can result in complete recovery or death within a few weeks without any symptoms of disease. Infection of mice in utero or within a few days of birth will result in lifelong shedding, growth retardation, eventual immune complex glomerulonephritis, and occasionally death. Human prenatal infection can be deadly and will almost always adversely affect brain function.
National Research Council (US) Committee on Infectious Diseases of Mice and Rats. Infectious Diseases of Mice and Rats. Washington (DC): National Academies Press (US); 1991.
Baker DG. Natural pathogens of laboratory mice, rats, and rabbits and their effects on research. Clin Microbiol Rev. 1998;11:231–266.
Waggie, Kimberly S. Manual of Microbiologic Monitoring of Laboratory Animals. U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Center for Research Resources, 1994.
“Lymphocytic choriomeningitis virus: an underrecognized cause of neurologic disease in the fetus, child, and adult” Seminars in pediatric neurology vol. 19,3 (2012): 89-95.