Research reagents for the detection of antibodies in animal sera by ELISA. Each ELISA plate is coated with Poliovirus strain BeAn 8386: The antigen is a purified inactivated whole virus propagated in BHK-21 cells. It will cross react with EMCV.
Theiler’s Murine Encephalomyelitis Virus (TMEV) is a single stranded RNA virus of the family Picornaviridae, genus Cardiovirus. The virus is spread through the fecal-oral route and shedding of the virus can occur for several months post-infection. Clinical signs of infection are not usually seen in laboratory mice. Rarely, the virus can disseminate from the intestine to the CNS, where it can cause demyelination of the spinal cord. Experimental TMEV infection in mice is often used as a model for multiple sclerosis, poliomyelitis, and virus-induced demyelinating disease. Laboratory mice and less frequently rats, and hamsters are hosts of the disease.
National Research Council (US) Committee on Infectious Diseases of Mice and Rats. Infectious Diseases of Mice and Rats. Washington (DC): National Academies Press (US); 1991.
Baker DG. Natural pathogens of laboratory mice, rats, and rabbits and their effects on research. Clin Microbiol Rev. 1998;11:231–266.
Waggie, Kimberly S. Manual of Microbiologic Monitoring of Laboratory Animals. U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Center for Research Resources, 1994.