COVID 19 – XpressBio is working diligently to ensure we keep our employees and their families safe, while maintaining our business continuity. Despite a “Stay At Home” advisory being put in place in Maryland, USA, we are deemed an essential business, and our manufacturing and distribution teams continue to be fully operational. We are continuing to work with our suppliers and distribution partners to ensure uninterrupted access to our products and technical support.
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Pigment epithelium-derived factor (PEDF) is a multipotent neurotrophic factor with potent activity both in the central nervous system and in the retina. To date, PEDF is the most potent angiogenic inhibitor found in the mammalian ocular compartment. Recent studies have shown that decreased ocular levels of PEDF are associated with diabetic retinopathy and other neuroretinal dystrophic diseases. In addition, the neurotropic and anti-angiogenic properties of PEDF suggest this protein is of potential therapeutic value for control of neovascularization associated with tumor growth. To facilitate research on this important member of the serpin protein superfamily, we have developed a sensitive PEDF ELISA using polyclonal antibodies that specifically detect native PEDF protein in human vitreous and other tissues.