Each plate is coated with Lactate dehydrogenase elevating virus (LDV): a recombinant nucleocapsid protein (VP1).
||8 × 5.25 × 0.75 in
48 Antigen Wells and 48 Control Antigen Wells
Lactate Dehydrogenase Elevating Virus (LDV) is a single stranded RNA virus of the family Togaviridae. Transmission occurs through contaminated tumors, cells, or serum in experimental procedures, but can also occur by direct contact via blood and saliva. The most notable pathological change due to LDV infection is an increase in lactate dehydrogenase in serum. Other pathological changes include reduction in thymus weight, and progressive limb paralysis. Elevated lactate dehydrogenase levels in serum and low-level virus titers can persist for life. Mice are the only hosts of the disease.
National Research Council (US) Committee on Infectious Diseases of Mice and Rats. Infectious Diseases of Mice and Rats. Washington (DC): National Academies Press (US); 1991.
Baker DG. Natural pathogens of laboratory mice, rats, and rabbits and their effects on research. Clin Microbiol Rev. 1998;11:231–266.
Waggie, Kimberly S. Manual of Microbiologic Monitoring of Laboratory Animals. U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Center for Research Resources, 1994.