Due to the hazards associated with Herpes B Virus, each plate is coated with HSV-1 (Herpes Simplex Virus Type 1) as a surrogate marker. It is a purified inactivated whole virus. It will cross react with HSV-2 (Herpes Simplex Virus Type 2) and other Herpes viruses.
Simian Herpes B Virus was initially identified in 1932. Both HSV1 and HSV2 share the same structure as B virus. In 2003, the B virus genome was able to be fully sequenced from a rhesus macaque due to its endemic nature. Although it is a simplex virus, B virus also falls under the category of an alpha herpesvirus. Using peripheral nerves, this subset of herpes is not identifiable within macaques’ bloodstreams and is neurotropic in manner. Macaques which have been infected often have minimal symptoms present or some none at all. Although infections are not common in humans, from 31 documented cases of human B virus infection, 21 were fatal. Contact from infected animals, bites, scratches, or body fluids can spread the infection. In non-fatal cases, there is a high degree of encephalitis present.